Search results for " surfac"
Article
Evaluating Surface Cleanliness Using a Risk-Based Approach
The process typically involves performing 100% spray coverage testing, rinse recovery testing, specific or non-specific analytical method qualification, surface sampling and recovery testing of the sa…
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Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
Blincyto targets cell surface proteins CD19 and CD3 simultaneously, helping to put T cells within reach of the targeted cancer cell with the goal of allowing the T cells to inject toxins into cancer c…
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Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
A unique characteristic of adherent cells is their dependence on an anchorage surface on which to attach to exert their normal metabolic activity and proliferate. While cell attachment may prove advan…
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Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
A possible solution to alleviate this is by using high-throughput potential tools such as surface plasmon resonance (SPR) to measure biomolecular interactions in real-time and in a label-free environm…
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PDA's Technical Report for Biotech Cleaning Validation
Differences between the cleaning of soils on those same surfaces also can be evaluated in the laboratory under simulated cleaning conditions.
These experiments enable employees to make determinati…
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
Founded in 2015, this company’s primary focus is to develop therapeutics with exosomal cargo and engineered surface ligands that can affect diseases, especially those with “undruggable” targets. Speci…
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Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
This has enabled design of experiment (DoE) approaches, such as response surface optimization, to be used. Second, better systems for collecting, storing, and analyzing process data have facilitated t…
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Virus-like Particles as Therapeutic Moieties of the Future
The uniformity and self-assembly of VLPs, along with their ability to withstand chemical modifications primarily on the outer surface, make them flexible and stable alternatives to nanoparticles, such…
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Process Chromatography: Continuous Optimization
IEX resins, according to Bulpin, have ionic groups on their surfaces comprising weak or strong acids (cation exchangers) or bases (anion exchangers). These groups discriminate between different macrom…
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Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
…mg/mL protein concentration) was prepared in a formulation that contained a buffering agent (10 mM), surfactant, cryoprotectant (disaccharide) and bulking agent (glycine). The formulation samples wer…